Characterization of Neospora caninum Surface Protein NcSRS2 Based on Baculovirus Expression System and Its Application for Serodiagnosis of Neospora Infection

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Characterization of Neospora caninum surface protein NcSRS2 based on baculovirus expression system and its application for serodiagnosis of Neospora infection.

The baculovirus expression system has proved to be a useful tool for the production of recombinant proteins. Here we have characterized the Neospora caninum surface protein NcSRS2 produced by two types of the recombinant virus and also have developed an enzyme-linked immunosorbent assay (ELISA) using recombinant NcSRS2 for the serologic diagnosis of Neospora infection. Western blot analysis sho...

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Protective efficacy of vaccination with Neospora caninum multiple recombinant antigens against experimental Neospora caninum infection.

Protective efficacy of vaccination with Neospora caninum multiple recombinant antigens against N. caninum infection was evaluated in vitro and in vivo. Two major immunodominant surface antigens (NcSAG1 and NcSRS2) and two dense granule proteins (NcDG1 and NcDG2) of N. caninum tachyzoites were expressed in E. coli, respectively. An in vitro neutralization assay using polyclonal antisera raised a...

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Neospora caninum and neosporosis

Neospora caninum is a protozoan cyst forming apicomplexan parasite that causes neosporosis, notably in cattle (Bos taurus) and domestic dogs (Canis familiaris) [1,2]. It is closely related to Toxoplasma gondii and has emerged as a major cause of reproductive failure in cattle worldwide [2]. The parasite was first described in a dog with encephalomyelitis and myositis [1] and was later described...

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ژورنال

عنوان ژورنال: Journal of Clinical Microbiology

سال: 2001

ISSN: 0095-1137,1098-660X

DOI: 10.1128/jcm.39.11.3987-3991.2001